Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors
This is a Phase I/II open label study of intravenous (IV) infusion of ONC-841 as a single agent or in combination in patients with advanced/metastatic solid tumors. The study will evaluate seven dose levels of ONC-841. The Phase 1 part is dose…
- Investigator
- Thomas J George
- Status
- Accepting Candidates
- Ages
- 18 Years - N/A
- Sexes
- All
ADC MATCH Screening and Treatment Trial
This phase II ADC MATCH screening and multi-sub-study treatment trial is evaluating whether biomarker-directed treatment with one of three antibody-drug conjugates (ADCs) (sacituzumab govitecan, enfortumab vedotin, and trastuzumab deruxtecan) works…
- Investigator
- Thomas J George
- Status
- Accepting Candidates
- Ages
- 18 Years - N/A
- Sexes
- All
A Phase II Platform Study to Evaluate Treatment in Patients with Colorectal Cancer
The NSABP FC-13 study is being done to determine if using immunotherapies alone or in combination with other drugs will delay or prevent colorectal cancer from coming back in patients with colorectal cancer who are ctDNA-positive after their…
- Investigator
- Thomas J George
- Status
- Accepting Candidates
- Ages
- 18 Years - N/A
- Sexes
- All