AZD0292 is a bispecific IgG1k mAb being evaluated for the prevention of exacerbations in bronchiectasis patients chronically colonized with PsA.
- Investigator
- Michael D Schweitzer Barrios
- Ages
- 12 Years - N/A
- Sexes
- All
Clinical trials
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D7700C00003 -
GNTI-122-T1D-1001 This is a 78-week single arm, multi-center, Phase 1 study to evaluate the safety, tolerability, cellular kinetics, and biomarker changes in C-peptide over time of GNTI-122, an investigational cell therapy manufactured from a participant's own blood…
- Investigator
- Brittany S Bruggeman
- Ages
- 18 Years - 45 Years
- Sexes
- All
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JXR CARD FRAN VICTORION-1 PREVENT CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at high cardiovascular…
- Investigator
- Francesco Franchi
- Ages
- 40 Years - 79 Years
- Sexes
- All
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RAN proteins in control and DM1 muscle and brain tissue -
DBS Severe ET Closed Loop This is a feasibility study based on physician-initiated Investigational Device Exemption (IDE) including intraoperative experiments and chronic testing of implanted dual thalamic DBS lead systems. This study will inform protocols for optimal use of…
- Ages
- 21 Years - 99 Years
- Sexes
- All
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Alpha/beta T cell and CD19+ B cell depletion in Allogeneic Stem Cell Transplantation This study will assess the safety, efficacy, and feasibility of ⍺/β CD3+ T-cell and CD19+ B-cell depletion in allogeneic stem cell transplantation in patients with acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), juvenile…
- Investigator
- Jordan Milner
- Ages
- 6 Months - 39 Years
- Sexes
- All
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Alpha/Beta T and B Cell depletion with Zoledronic acid for solid tumors Hematopoietic stem cell transplantation can cure patients with blood cancer and other underlying diseases. αβ-T cell and B cell depletion has been introduced to decrease GVHD and PTLD and has demonstrated effectiveness for hematologic malignancies…
- Investigator
- Jordan Milner
- Ages
- 6 Months - 25 Years
- Sexes
- All
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Safety, PK/PD, and Exploratory Efficacy of AMT-191 in Classic Fabry Disease The main goals of this clinical study are to characterize safety and PK/PD of AMT-191 i.e. if drug doses used in the study are safe and tolerable and to understand how it acts in the body of people with Fabry disease.
- Investigator
- Coy Heldermon
- Ages
- 18 Years - 50 Years
- Sexes
- Male
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DIFI This study evaluates the efficacy and safety of a single injection of iltamiocel (300 x 10^6 cells) compared to a placebo in the reduction of fecal incontinence episode frequency in adult female participants with chronic fecal incontinence and a…
- Investigator
- Johan Nordenstam
- Ages
- 18 Years - N/A
- Sexes
- Female
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DREAM The overriding objective of DREAM is to conduct a prospective longitudinal (36 months) observational clinical study to investigate the incidence, etiology, and pathophysiology of diabetes mellitus (DM) following acute pancreatitis (AP).
- Investigator
- Chris Forsmark
- Ages
- 18 Years - 75 Years
- Sexes
- All