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Gastroschisis is a birth defect in which an infant's intestines are outside of the body because of a hole in the abdominal wall.

Alternative Names

Birth defect - gastroschisis; Abdominal wall defect - infant; Abdominal wall defect - neonate; Abdominal wall defect - newborn


Babies with gastroschisis are born with a hole in the abdominal wall. The child's intestines often stick out (protrude) through the hole.

The condition looks similar to an omphalocele. An omphalocele, however, is a birth defect in which the infant's intestine or other abdominal organs protrude through a hole in the belly button area and are covered with a membrane. With gastroschisis, there is no covering membrane.

Abdominal wall defects develop as a baby grows inside the mother's womb. During development, the intestine and other organs (liver, bladder, stomach, and ovaries, or testes) develop outside the body at first and then usually return inside. In babies with gastroschisis, the intestines (and sometimes the stomach) remain outside the abdominal wall, without a membrane covering them. The exact cause of abdominal wall defects is not known.

Mothers with the following may be at higher risk of having babies with gastroschisis:

  • Younger age
  • Fewer resources
  • Poor nutrition during pregnancy
  • Use of tobacco, illicit drugs, and alcohol
  • Exposure to nitrosamine (a chemical found in some foods, cosmetics, cigarettes)
  • Use of aspirin or ibuprofen
  • Use of decongestants that have the chemical pseudoephedrine or phenylpropanolamine

Babies with gastroschisis usually do not have other related birth defects.


A gastroschisis is usually seen during a prenatal ultrasound. It can also be seen when the baby is born. There is a hole in the abdominal wall. The small intestine is often outside the abdomen near the umbilical cord. Other organs that may also be outside the abdomen are the large intestine, stomach, and/or gallbladder.

Usually the intestine is irritated by the exposure to amniotic fluid. The baby may have problems absorbing food.

Exams and Tests

Prenatal ultrasounds often identify infants with gastroschisis before birth, usually by 20 weeks of pregnancy.


If gastroschisis is found before birth, the mother will need special monitoring to make sure her unborn baby remains healthy.

Treatment for gastroschisis involves surgery. Usually the infant's abdominal cavity is too small for the intestine to fit back in at birth. So, a mesh sack is stitched around the borders of the defect and the edges of the defect are pulled up. The sack is called a silo. Over the next week or two, the intestine returns into the abdominal cavity and the defect can then be closed.

The baby's temperature must be carefully controlled, because the exposed intestine allows body heat to escape. Because of the pressure involved in returning the intestines to the abdomen, the baby may need breathing support with a ventilator. Other treatments for the baby include nutrients by IV and antibiotics to prevent infection. Even after the defect is closed, IV nutrition will continue as milk feedings must be introduced slowly.

Outlook (Prognosis)

The baby has a good chance of recovering if there are no other problems and if the abdominal cavity is large enough. A very small abdominal cavity may result in complications that require more surgeries.

Plans should be made for careful delivery and immediate management of the problem after birth. The baby should be delivered in a medical center that is skilled at repairing abdominal wall defects. Babies are likely to do better if they do not need to be taken to another center for further treatment.

Possible Complications

Because of the exposure to amniotic fluid, babies' intestines may not work normally even after the organs are put back inside the abdominal cavity. Babies with gastroschisis need time for their intestines to recover and become used to taking feedings.

A small number of babies with gastroschisis (about 10 to 20%) may have intestinal atresia (parts of the intestines that did not develop in the womb). These babies require further surgery to relieve obstruction.

The increased pressure from the misplaced abdominal contents can decrease blood flow to the intestines and kidneys and cause more long-term damage. It can also make it difficult for the baby to expand the lungs, leading to breathing problems.

Another possible complication is bowel death leading to necrosis of the bowel. This occurs when intestinal tissue dies due to low blood flow or infection. This risk may be reduced in babies who receive breast milk rather than formula.

This condition (gastroschisis) is apparent at birth and will be detected in the hospital at delivery if it has not already been seen on routine fetal ultrasound exams during pregnancy. If you have given birth at home and your baby appears to have this defect, call 911 or the local emergency number right away.

When to Contact a Medical Professional

This problem is diagnosed and treated in the hospital right after birth. After returning home, contact your health care provider if your baby develops any of these symptoms:

  • Decreased bowel movements
  • Feeding problems
  • Fever
  • Green or yellowish green vomit
  • Swollen belly area
  • Vomiting (different than normal baby spit-up)
  • Worrisome behavioral changes


Infant abdominal hernia (gastroschisis)
An abdominal hernia (gastroschisis) occurs when there is an area where the muscles are weak, and this allows the internal organs to bulge through the abdominal wall.
Gastroschisis repair - series
In the womb, fetal intestines develop outside of the abdomen for a brief time. Normally, the intestines return to the abdominal cavity and the abdomen is closed at birth.
Gastroschisis repair - series
In the womb, fetal intestines develop outside of the abdomen for a brief time. Normally, the intestines return to the abdominal cavity and the abdomen is closed at birth.


Centers for Disease Control and Prevention website. Facts about gastroschisis. Updated June 28, 2023. Accessed March 14, 2024.

Islam S. Congenital abdominal wall defects: gastroschisis and omphalocele. In: Holcomb GW, Murphy JP, St. Peter SD, eds. Holcomb and Ashcraft's Pediatric Surgery. 7th ed. Philadelphia, PA: Elsevier; 2020:chap 48.

Polites S, Nathan JD. Newborn abdominal wall defects. In: Wyllie R, Hyams JS, Kay M, eds. Pediatric Gastrointestinal and Liver Disease. 6th ed. Philadelphia, PA: Elsevier; 2021:chap 58.

Last reviewed December 31, 2023 by Mary J. Terrell, MD, IBCLC, Neonatologist, Cape Fear Valley Medical Center, Fayetteville, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team..

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