Fat in muscle hastens limb loss, study shows
March 10, 2026
GAINESVILLE, Fla. — For decades, treatment of peripheral artery disease has focused almost exclusively on restoring blood flow. Now, new research from…
College of Medicine, +1 more
Leg pain is a common problem. It can be due to a cramp, injury, or other cause.
Pain - leg; Aches - leg; Cramps - leg
Leg pain can be due to a muscle cramp (also called a charley horse). Common causes of cramps include:
An injury can also cause leg pain from:
Other common causes of leg pain include:
Less common causes include:
If you have leg pain from cramps or overuse, take these steps first:
Other homecare will depend on the cause of your leg pain.
Contact your health care provider if:
Your provider will perform a physical exam and look at your legs, feet, thighs, hips, back, knees, and ankles.
Your provider may ask questions such as:
Your provider may recommend tests or physical therapy for some causes of leg pain.
Anthony KK, Schanberg LE. Musculoskeletal pain syndromes. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 193.
Hogrefe C, Terry M. Leg pain and exertional compartment syndromes. In: Miller MD, Thompson SR. eds. DeLee, Drez, & Miller's Orthopaedic Sports Medicine. 5th ed. Philadelphia, PA: Elsevier; 2020:chap 113.
Silverstein JA, Moeller JL, Hutchinson MR. Common issues in orthopedics. In: Rakel RE, Rakel DP, eds. Textbook of Family Medicine. 9th ed. Philadelphia, PA: Elsevier; 2016:chap 30.
Smith G, Shy ME. Peripheral neuropathies. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.
Weitz JI, Eikelboom JW. Venous thrombosis and embolism. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 68.
White CJ. Atherosclerotic peripheral arterial disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 65.
March 10, 2026
GAINESVILLE, Fla. — For decades, treatment of peripheral artery disease has focused almost exclusively on restoring blood flow. Now, new research from…
College of Medicine, +1 more
As both a UF Health Shands team member and the mother of a patient, Taylor Smith, RN, sees UF Health as more than a workplace — it’s part of her family’s…