Michael Clare-Salzler, M.D.

Michael J Clare-Salzler, M.D.

(352) 273-8655

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Publications

The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).
Diabetologia
2021

The Hologic Aptima SARS-CoV-2 assay enables high ratio pooling saving reagents and improving turnaround time.
Journal of clinical laboratory analysis
2021

Predictors of oxylipins in a healthy pediatric population.
Pediatric research
2021

Pathology Informatics and Robotics Strategies for Improving Efficiency of COVID-19 Pooled Testing.
Academic pathology
2021

Collection and Storage of Human Plasma for Measurement of Oxylipins.
Metabolites
2021

Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti-Citrullinated Protein Antibody-Positive Population.
Arthritis & rheumatology (Hoboken, N.J.)
2021

Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.
JAMIA open
2020

Informatics Training for Pathology Practice and Research in the Digital Era.
Academic pathology
2020

Vitamin D and Omega 3 Field Study on Progression of Type 1 Diabetes.
CellR4-- repair, replacement, regeneration, & reprogramming
2019

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Nature
2019

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes.
Nutrients
2019

Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering
2019

CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics
2019

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions
2018

Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science
2018

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice.
Journal of immunology research
2018

Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection.
Clinical immunology (Orlando, Fla.)
2018

Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials
2018

Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.
Diabetes
2017

Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas.
EBioMedicine
2017

The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population.
Rheumatology (Oxford, England)
2017

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis.
Annals of the rheumatic diseases
2017

Macrophage integrins modulate response to ultra-high molecular weight polyethylene particles and direct particle-induced osteolysis.
Biomaterials
2017

Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics
2017

Enrichment of IL-17A+ IFN-γ+ and IL-22+ IFN-γ+ T cell subsets is associated with reduction of NKp44+ ILC3s in the terminal ileum of Crohn's disease patients.
Clinical and experimental immunology
2017

Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis.
BMJ open diabetes research & care
2016

Restoring immune tolerance in neuromyelitis optica: Part II.
Neurology(R) neuroimmunology & neuroinflammation
2016

Restoring immune tolerance in neuromyelitis optica: Part I.
Neurology(R) neuroimmunology & neuroinflammation
2016

Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens.
International immunopharmacology
2016

Micro and Nano Material Carriers for Immunomodulation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2016

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study.
Rheumatology (Oxford, England)
2016

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria.
Chemistry (Weinheim an der Bergstrasse, Germany)
2016

A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation.
Journal of materials chemistry. B
2016

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.
Current diabetes reports
2015

Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes.
Pediatric diabetes
2015

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease.
Diabetes care
2015

Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics
2015

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
Clinical immunology (Orlando, Fla.)
2015

It's time to bring dendritic cell therapy to type 1 diabetes.
Diabetes
2014

Integrin-directed modulation of macrophage responses to biomaterials.
Biomaterials
2014

Infection and persistence of erythrovirus B19 in benign and cancerous thyroid tissues.
Journal of medical virology
2014

Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950)
2014

Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young.
Diabetologia
2014

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.
Journal of materials chemistry. B
2014

Clinical pharmacogenetics implementation: approaches, successes, and challenges.
American journal of medical genetics. Part C, Seminars in medical genetics
2014

Characterization of Bone Marrow-Derived Dendritic Cells Developed in Serum-Free Media and their Ability to Prevent Type 1 Diabetes in Nonobese Diabetic Mice.
Journal of blood disorders & transfusion
2014

C-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2.
PloS one
2014

Anti-CD3 antibody treatment induces hypoglycemia and super tolerance to glucose challenge in mice through enhancing glucose consumption by activated lymphocytes.
Journal of immunology research
2014

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.
Clinical pharmacology and therapeutics
2013

Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.
PloS one
2013

Omega-3 Supplement Use Is Associated With a Reduced Risk of Anti-Cyclic Citrullinated Protein Positivity in a Population Without Rheumatoid Arthritis, But At Risk for Future Disease
Arthritis and Rheumatism
2013

Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.
Pharmacogenomics
2013

Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
2013

Anti-lymphocyte antibody-based immunotherapy in type 1 diabetes.
Chinese medical journal
2013

Total synthesis of grassystatin A, a probe for cathepsin E function.
Bioorganic & medicinal chemistry
2012

The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
PloS one
2012

Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation.
Transplant infectious disease : an official journal of the Transplantation Society
2012

Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Clinical pharmacology and therapeutics
2012

Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology
2012

Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood
2012

University of Florida Clinical and Translational Science Institute: transformation and translation in personalized medicine.
Clinical and translational science
2011

Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes
2011

Parvovirus B19 infection in Hashimoto's thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association
2011

Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes.
Human vaccines
2011

Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).
Pediatric diabetes
2011

Adhesive substrates modulate the activation and stimulatory capacity of non-obese diabetic mouse-derived dendritic cells.
Acta biomaterialia
2011

The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates.
Biomaterials
2010

Hyper-responsive phenotype in localized aggressive periodontitis.
Journal of dental research
2010

Experimental extracorporeal photopheresis therapy significantly delays the development of diabetes in non-obese diabetic mice.
Clinical immunology (Orlando, Fla.)
2010

Erythrocyte membrane fatty acid content in infants consuming formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): an observational study.
Maternal & child nutrition
2010

Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipients.
Transplantation
2010

Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950)
2009

Extracorporeal photopheresis-induced immune tolerance: a focus on modulation of antigen-presenting cells and induction of regulatory T cells by apoptotic cells.
Current opinion in organ transplantation
2009

Dendritic Cell Therapy for Prevention of Type 1 Diabetes: Role of Peptide Presentation On Immune Modulation
Clinical Immunology
2009

Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation
2009

A high-throughput microparticle microarray platform for dendritic cell-targeting vaccines.
Biomaterials
2009

Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes
2008

Infusion of UVB-treated splenic stromal cells induces suppression of beta cell antigen-specific T cell responses in NOD mice.
Journal of autoimmunity
2008

Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children.
European journal of clinical nutrition
2008

Apoptotic non-beta cells suppress beta cell antigen-reactive T cells and induce beta cell antigen-specific regulatory T cells.
Annals of the New York Academy of Sciences
2008

Adhesive substrate-modulation of adaptive immune responses.
Biomaterials
2008

Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.
Journal of immunology (Baltimore, Md. : 1950)
2007

Truncated pStat5B is associated with the Idd4 locus in NOD mice.
Biochemical and biophysical research communications
2007

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood
2007

Transfusion of apoptotic beta-cells induces immune tolerance to beta-cell antigens and prevents type 1 diabetes in NOD mice.
Diabetes
2007

Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes.
JAMA
2007

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
Diabetes
2007

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine
2007

Dendritic cells post-maturation are reprogrammed with heightened IFN-gamma and IL-10.
Biochemical and biophysical research communications
2007

Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesis.
Annals of the New York Academy of Sciences
2006

Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetes.
Annals of the New York Academy of Sciences
2006

Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes
2006

Heightened interferon-alpha/beta response causes myeloid cell dysfunction and promotes T1D pathogenesis in NOD mice.
Annals of the New York Academy of Sciences
2006

Eicosanoid imbalance in the NOD mouse is related to a dysregulation in soluble epoxide hydrolase and 15-PGDH expression.
Annals of the New York Academy of Sciences
2006

Dendritic cell subsets and type I diabetes: focus upon DC-based therapy.
Autoimmunity reviews
2006

The effects of renal transplantation on peripheral blood dendritic cells.
Clinical transplantation
2005

The effects of renal transplantation on circulating precursor dendritic cells.
Transplantation proceedings
2005

Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages.
Journal of autoimmunity
2005

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950)
2005

In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases.
Scandinavian journal of immunology
2005

Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.)
2005

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes
2005

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology
2005

Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity.
Scandinavian journal of immunology
2005

CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2005

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?
Pediatric Diabetes
2004

IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes.
Journal of autoimmunity
2004

Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2004

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950)
2003

Defective maturation of myeloid dendritic cell (DC) in NOD mice is controlled by IDD10/17/18.
Annals of the New York Academy of Sciences
2003

CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity
2003

Abnormal peripheral blood dendritic cell populations in type 1 diabetes.
Annals of the New York Academy of Sciences
2003

Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes
2003

Indomethacin, dexamethasone, and intestinal damage in infant rats.
Journal of pediatric gastroenterology and nutrition
2002

Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
2002

Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes.
Annals of the New York Academy of Sciences
2002

Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
2001

Apoptosis in sepsis: a new target for therapeutic exploration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2001

Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of immunology (Baltimore, Md. : 1950)
2000

Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.
American journal of physiology. Regulatory, integrative and comparative physiology
2000

Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production.
Journal of immunology (Baltimore, Md. : 1950)
2000

No alteration in T lymphocyte expression of CD40 ligand (CD154) in individuals with or at increased risk for insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism
1999

Caspase-3-dependent organ apoptosis early after burn injury.
Annals of surgery
1999

Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation
1999

Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.
Journal of applied physiology (Bethesda, Md. : 1985)
1998

Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
1998

Systemic infection of mice by wild-type but not Spv- Salmonella typhimurium is enhanced by neutralization of gamma interferon and tumor necrosis factor alpha.
Infection and immunity
1997

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Journal of immunology (Baltimore, Md. : 1950)
1997

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
The Journal of experimental medicine
1996

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nature medicine
1996

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
The Journal of clinical investigation
1995

Essential fatty acid deficiency prevents autoimmune diabetes in nonobese diabetic mice through a positive impact on antigen-presenting cells and Th2 lymphocytes.
Pancreas
1995

Down-regulation of blood-brain glucose transport in the hyperglycemic nonobese diabetic mouse.
Neurochemical research
1995

Effect of H-2 compatibility in autoimmune destruction of islet allografts from B10 congenic lines to nonobese diabetic mice.
Pancreas
1994

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Nature
1993

Permanent diabetes developing after transient neonatal diabetes.
Lancet (London, England)
1993

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.
The Journal of experimental medicine
1993

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.
The Journal of clinical investigation
1992

Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.
Diabetes care
1992

Marked dendritic cell-T cell cluster formation in the pancreatic lymph node of the non-obese diabetic mouse.
Immunology
1992

Glutamate decarboxylase: an autoantigen in IDDM.
Diabetes care
1992

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
The Journal of clinical investigation
1992

Thyroid function abnormalities associated with the chronic outpatient administration of recombinant interleukin-2 and recombinant interferon-alpha.
Journal of immunotherapy : official journal of the Society for Biological Therapy
1991

Endocardial metastases of follicular thyroid carcinoma: a case report and review of the literature.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
1991

Prolongation of islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-LYT2 monoclonal antibodies.
Transplantation proceedings
1990

Destruction of islet isografts by severe nonspecific inflammation.
Transplantation proceedings
1990

Islet transplantation for the cure of diabetes.
Pancreas
1989

Fetal pancreas transplantation in miniature swine. II. Survival of fetal pig pancreas allografts cultured at room temperature.
Diabetes
1989

Research Interests

  • Dr. Clare-Salzler's research focus is to establish the cellular, molecular, and genetic basis for the immunpathogenesis of Juvenile or Type I diabetes and other autoimmune endocrine diseases. He and his team have concentrated their efforts on the role of antigens such as glutamate decarboxylase (GAD) and the biology of antigen presenting cells as it relates to the generation of protective and pathogenic immune responses in an animal model of Type I diabetes, the non-obese diabetic mouse (NOD) as well as in humans with an established high risk for this disease.
  • Recent work has lead to the identification of a number of immunophenotypes in NOD mice and human subjects with a high risk for Type I diabetes. These immunophenotypes involve the regulation of prostaglandin metabolism in macrophages/monocytes and dysregulation of pathways involved in activation induced cell death in lymphocytes. Utilizing congenic mice we have identified chromosomal intervals that contribute to these phenotypes. They are currently evaluating candidate genes in these intervals and are also determining the role of TNF in the development of organ dysfunction, particularly liver injury, in a murine model of sepsis and inflammation. The team has defined that NOD mice are highly resistant to this form of liver injury in comparison to other standard strains of mice. They are currently dissecting the genetic contributions to this resistance using a congenic mouse approach.