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(352) 273-6415

For providers

Information for health care providers on how to refer patients to MyRX and how to interpret the results of the testing.

Refer a patient UF Health provider referrals

How can pharmacogenetic testing help inform medication response?

Often we use medications as a one-size-fits-all-approach, which may be successful for some patients but not for others. Personalized medicine is an innovative approach to tailoring medications that takes into account differences in people’s genes, other medications, and clinical factors. The goal of personalized medicine is to target the right treatments to the right patients at the right time.

Differences in genes that code for drug transporters or metabolizing enzymes can impact a body’s total exposure to a drug. Exposure is often related to effectiveness and toxicity – too little and the drug won’t work, too much and the drug causes side effects. In the same way a person with declining kidney function will build up levels of certain drugs, a person with a decreased-function drug metabolizing enzyme will build up levels of active drug.

Most people have at least 1 variant of a pharmacogene that might affect medication therapy throughout their life.1-3 So far, there over 300 drugs with PGx information in their FDA label, including 11 with boxed warnings.

References

1Pharmacogenomics: The case for provider practice integration. GenoPATH.
2Scharfe CPI, et al. Genetic variation in human drug-related genes. Genome Med. 2017;9(1):117.
3Van Driest SL, et al. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clin Pharmacol Ther. 2013;95(4):423-31.

How to refer patients

Register on website

Direct your patient to the MyRx.ufhealth.org website and patient portal to register. (click “register and get started”).

Fax your referral

Fax us your referral to us at (352) 627-4121.

Brochures and tip sheets

Request provider tip sheet and patient-friendly brochures.

Once your patient registers with MyRx, they can provide us with your information, so you receive their individualized consult (includes pharmacogenetic test result interpretation and recommendations for current and future medications).

  • If the patient does not provide MyRx with their provider information, the individualized consult will be provided directly to the patient.
  • It is the patient's responsibility to share the consult with their provider to aid with medication decisions and changes.
Pricing information

For UF Health providers

  1. Direct your patient to this website and instruct them to click “Register & Get Started” in the top-right corner.
    • Provide your patient a brochure and have them scan the QR code
    • Use the smart phrase “.MyRx” in patient instructions, which will instruct them to go to the website to register
  2. Place electronic referral in Epic
    • “Appt Req Pharmacogenetics” (REF853)
  3. Place electronic order for pharmacogenetic test in Epic
    • “Gator PGx” LAB12305000

MyRx will take it from there! We will contact your patient and place an individualized consult in their Epic chart routed to you for review.

Educational resources

How to interpret results

Tables providing clinical interpretation and recommendations based on pharmacogenetic results.

Phenoconversion calculator

The PROP™ Pharmacogenetics Calculator is intended to help clinicians integrate a standardized method of assessing CYP2D6 phenoconversion into practice when a CYP2D6 genotype is available. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of either limited experience on how to integrate or lack of knowledge that it has occurred.

  • Clinical Pharmacogenomic Implementation Consortium
    Expert-reviewed guidelines for drug-gene pair implementation, standardized terminology and other resources.
  • PharmGKB
    Searchable pharmacogenetic database that allows clinicians, students and researchers to search for pharmacogenetic information on drugs, genes, variants, regulatory resources and implementation resources.
  • FDA Table of Pharmacogenetic Associations
    Table of pharmacogenetic associations that are related to drug metabolizing enzyme gene variants, drug transporter gene variants, and gene variants that have been related to a predisposition for certain adverse events.

A note from Dr. Molly Posa

“I have used genetic testing to create a treatment plan for my patients with depression and anxiety,” said Molly Posa, M.D., an associate professor of pediatrics in the UF College of Medicine. “I am grateful for the MyRx program, and the information it provides to help select the most effective medication for my patients. It’s an invaluable tool in my clinical evaluation and decision-making process.”